Magnetic anisotropy in the hexagonal RET5 compounds
B.
El-Assy
Department of Physics, Faculty of Women, Ain - Shams University, Cairo, Egypt.
author
A.
Dakrory
Department of Physics, Faculty of Women, Ain - Shams University, Cairo, Egypt.
author
S.
Aly
Department of Physics, Faculty of Science, Damietta University, Damietta, Egypt.
author
M.
Yehia
Department of Physics, Faculty of Science, Helwan University, Cairo, Egypt.
author
text
article
2018
eng
Using the methods of classical statistical mechanics, the field dependence of magnetization curves is calculated at room temperature for SmCo5, PrCo5 and YCo5. In addition, we discuss the dependence of the magnetization vector on the direction of the magnetic field, along and perpendicular to the easy-axis. We correlate the orientation of the magnetization vector, relative to a specific crystallographic axis, to the angular coordinates of the most probable location in a probability landscape of these anisotropic magnetic systems.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2018
1
10
https://jsrs.journals.ekb.eg/article_19940_294c505f6e5f633c8ff90490c8674fa5.pdf
dx.doi.org/10.21608/jsrs.2018.19940
Accurate Fiber Length Measurements Using Time-Of-Flight Technique
Osama
Terra
National Institute for Standard (NIS), Tersa St. Haram, code: 12211, P.O.Box: 136 Giza, Egypt.
author
Hatem
Hussein
National Institute for Standard (NIS), Tersa St. Haram, code: 12211, P.O.Box: 136 Giza, Egypt.
author
text
article
2018
eng
Fiber artifacts of very well measured lengths are required for the calibration of optical time-domain reflectometers (OTDR). In this paper, accurate length measurement of different fiber lengths using the time-of-flight technique is performed. A setup is proposed to measure accurately lengths from 1 km to 40 km at 1550 nm and 1310 nm using a high speed electro-optic modulator, a photodetector and a time interval counter (TIC). This setup offers traceability to the SI unit of time, the second, (and hence to the meter by definition) by locking the time interval counter to the GPS-disciplined quartz oscillator. Additionally, the length of a recirculating loop artifact is measured and compared with the measurement made for the same fiber by the National physical laboratory of United Kingdom (NPL). Finally, a method is proposed to relatively correct the fiber refractive index to allow accurate fiber length measurement.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2018
11
19
https://jsrs.journals.ekb.eg/article_19941_e085ff3f34790ba52bf72b081a99647e.pdf
dx.doi.org/10.21608/jsrs.2018.19941
Assessment of natural radioactivity levels in phosphate rocks from Wadi Qena and Abu-Tartor mine in Egypt
S.
Darwish
a Physics Department, Faculty of Science, Cairo University, Giza, Orman, Postal Code 12613, Egypt
author
N.
WalleyEl –Dine
Physics Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Egypt
author
T.
Ibrahim
Geological Studies Department , Nuclear Material Authority, Cairo, Egypt
author
H.
Emad
Physics Department, Faculty of Science, Cairo University, Giza, Orman, Postal Code 12613, Egypt
author
text
article
2018
eng
The activity concentration of 235U, 238U, 234mPa, 226Ra, 232Th and 40K were determined using gamma ray spectrometry with a high-purity germanium (HPGe) detector for eighteen samples of phosphate rocks collected from Wadi Qena and Abu-Tartor mine. To obtain the exact information about the measurement of 238U by gamma-ray spectroscopy, it is essential that any one of the daughters of 238U should exist in equilibrium with 238U. This condition is fulfilled by taking the average of all present measurements of daughters of 238U, namely 234mPa, 226Ra, 214Bi and 214Pb. The average activity concentration for phosphate rocks of Wadi Qena are 52.31, 864.69, 54.14 and 87.39 for 235U, 238U, 232Th and 40K, respectively, while that of Abu-Tartor are 24.80, 419.13, 48.21 and 115.95 for 235U, 238U, 232Th and 40K, respectively. The results were compared with different locations in Egypt and the world abroad reported in the literature. The radiation hazard to the occupational workers and public, the radium equivalent activities in Bq/kg, external and internal hazards and dose rate in nGy/hr are calculated. It seems that Abu-Tartor phosphate deposit has the lowest radioactivity level for 235U, 238U and 232Th of exploited phosphate of sedimentary origin.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2018
20
38
https://jsrs.journals.ekb.eg/article_19942_600513c4cf3dbaada74cc795a9a2572d.pdf
dx.doi.org/10.21608/jsrs.2018.19942
Structural and electrical properties of Sprayed ZnO:Al thin films
Fawzy
Mahmoud
Solid State Physics Dept., National Research Center, P.O. 12311, Dokki, Giza, Egypt
author
Hagar
Mohamed
Solid State Physics Dept., National Research Center, P.O. 12311, Dokki, Giza, Egypt
author
M.B.S.
Osman
Physics Department, Faculty of Women for Arts, Science and Education
, Ain Shams University, Heliopolis, Cairo, Egypt
author
text
article
2018
eng
Aluminium doped zinc oxide (AZO) thin films were prepared on glass substrates by spray pyrolysis technique. The Al concentration in the starting solution was varied from (0 to 5) wt %. XRD revealed that both pure and AZO thin films were polycrystalline with hexagonal structure and exhibited (002) preferential orientation. AZO film with minimum electrical resistivity 8.61×10 ³⁻ Ω.cm were obtained at a doping ratio of 2 wt. %.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2018
39
46
https://jsrs.journals.ekb.eg/article_19943_3390e77a4f3a886f2eef17ecf7fa8eec.pdf
dx.doi.org/10.21608/jsrs.2018.19943
Operating Conditions Dependence of the Junction Characteristics of Optocouplers
W.
Abdelbasit
Electronic Research Lab., Physics Dept., Faculty of Women for Arts,
Science, and Education, Ain-Shams University, Cairo, Egypt.
author
W.
Hassan
Electronic Research Lab., Physics Dept., Faculty of Women for Arts,
Science, and Education, Ain-Shams University, Cairo, Egypt.
author
F.
Soliman
Nuclear Materials Authority, P.O.Box 530, Maadi-11728, Cairo, Egypt.
author
S.
Kamh
Electronic Research Lab., Physics Dept., Faculty of Women for Arts,
Science, and Education, Ain-Shams University, Cairo, Egypt.
author
text
article
2018
eng
The present paper is a trial to shed further light on the dependence of the junction characteristics of the proposed optocoupler type 4N25 on the operating conditions; the applied voltage and signal frequency. For the input light emitting diode and output phototransistor, their forward and reverse (C–V) characteristics were investigated and plotted at different applied bias voltage- and frequency- levels. In this concern, the diffusion- and transition- capacitances, impedance, quality- and dissipation- factors, and the phase angle were investigated. Concerning the light emitting diode, at frequency value of 200 kHz, as an example, the diffusion capacitance value increases exponentially from 0.166 nF, up to 4.71 nF, measured at forward bias voltages of 0.01 Volt and 1.20 Volts, respectively. Also, at an applied forward bias voltage of 1.0 Volts, the diffusion capacitance increases from 1.76 nF up to 2.84 nF, measured at frequency levels of 50 kHz and 300 kHz, respectively. Considering the transition capacitance, and at signal frequency of 200 kHz, its value was shown to be decreased rapidly from 178.36 pF down to 30.42 pF whenever measured at 0.01 Volt and 0.30 Volt, respectively. But for higher bias voltages, the decreasing rate was shown to be negligible. On the other hand, at applied bias voltage of 1.0 Volt, its value was shown to be decreased from 28.76 pF down to 17.59 pF, measured at frequency levels of 50 kHz and 300 kHz. For the phototransistor, its emitter junction capacitance increased exponentially as a function of the emitter-base bias voltage, where at frequency of 200 kHz, as an example, its value increased from 0.581 nF up to 3.048 nF, measured at 0.01 Volt and 0.80 Volt, respectively. On the other hand, the collector junction capacitance was shown to be decayed rapidly as a function of the applied reverse bias voltage. Where its value decreased from 1.29 nF down to 0.012 nF, measured at 0.01 Volt and 0.90 Volt, at frequency of 200 kHz, as an example. Finally, it is proved that for both capacitances, their values are a direct decreasing functions of the operating frequency, where at applied bias voltage of 0.8 Volt, a values of 7.6878 nF and 0.05338 nF were decreased down to 1.811 nF and 0.0254 nF, respectively, with increasing the frequency from 50 kHz up to 300 kHz.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2018
47
61
https://jsrs.journals.ekb.eg/article_19944_1b8e938222f23254f89a6c0911b2cb25.pdf
dx.doi.org/10.21608/jsrs.2018.19944
Assessment of the Natural Radioactivity and its Radiological Hazards in Stream Sediments at Gulf of Al Aqaba, Sinai, Egypt.
M.
Ibrahim
Nuclear Material Authority, Egypt.
author
N.
Walley elDine
Physics Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Egypt
author
A.
EL-Shershaby
Faculty of women for Arts, Science and Education, Ain Shams University, Cairo, Egypt.
author
S.
EL-Bahi
Faculty of women for Arts, Science and Education, Ain Shams University, Cairo, Egypt.
author
N.
Ali
Faculty of women for Arts, Science and Education, Ain Shams University, Cairo, Egypt.
author
text
article
2015
eng
Specific activities and distribution of natural radionuclides gamma emitting from238U, 232Th and 40K in stream sediment samples were calculated. The samples were collected from different locations from western port of Gulf of Al- Aqaba have been carried out using the high-purity germanium (HPGe) detector. The activity concentrations of most samples are higher than the permissible level for 238U, 232Th and 40K. The radium equivalent (Raeq), the external hazard index (Hex) and effective dose rate were estimated for the radiation hazard of the natural radioactivity. The calculated values are higher than the recommended limit. The harmful radiation effects are posing to the public and tourists going to the area under investigation.
Also the specific activities of the samples were calculated using radiometric analysis with NaI(TI) detector, the obtained results from the two techniques confirmed each other. Consequently, this area is not safe for use as different activities.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
62
75
https://jsrs.journals.ekb.eg/article_19946_58d19aa13cb2a268b1d47a2cbf1b65bf.pdf
dx.doi.org/10.21608/jsrs.2015.19946
ABSOLUTE DISTANCE MEASUREMENT USING FREQUENCY SCANNING INTERFEROMETRY
M.
Medhat
Physics Department. Faculty of Science. Ain-Shams University, Cairo, Egypt
author
M.
Sobee
National Institute for Standard (NIS), Tersa St. Haram, code:12211, P.O.Box: 136 Giza, Egypt
author
H.
Hussein
National Institute for Standard (NIS), Tersa St. Haram, code:12211, P.O.Box: 136 Giza, Egypt
author
O.
Terra
National Institute for Standard (NIS), Tersa St. Haram, code:12211, P.O.Box: 136 Giza, Egypt
author
text
article
2015
eng
Absolute distance measurement is necessary for many applications where the distance to a fixed-target is required. In this paper, frequency scanning interferometry is implemented with an external cavity tunable diode laser, which has a wavelength scanning range of (665-675 nm), to measure distances up to 5 m absolutely (achieved by multi-reflection system). An ultra-low expansion (ULE) Fabry-Pérot (FP) cavity has been used as a reference to measure the tunable-laser scanning range. Absolute distance is determined by counting the synthetic fringes and FP peaks simultaneously while scanning the laser frequency. A fringe processing technique is developed to perform online distance measurement even though the tunable laser is not mode-hop free. This fringe processing method enables simple, fast and accurate distance measurements with repeatability ±3.9×10-6 L and combined uncertainty ±38.9×10-6 L which is limited by the calibration system used.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
76
88
https://jsrs.journals.ekb.eg/article_19947_2931af57baed99f3a2f32acaec6cbbf2.pdf
dx.doi.org/10.21608/jsrs.2015.19947
Preparation and Characterization of Al Matrix Composites Reinforced with (20-x) wt.-% Al2O3 - (x) ZrO2
Mahmoud
Zawrah
Ceramics Department, National Research Center , Dokki, Cairo, Egypt.
author
Mohammed
Taha
Solid State Physics Department, National Research Center, Dokki, Cairo, Egypt.
author
F.
Saadallah
Solid State Physics Department, National Research Center, Dokki, Cairo, Egypt.
author
A.
Mostafa
Physics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
author
M.
Hassan
Physics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
author
Mahmoud
Nasr
Solid State Physics Department, National Research Center, Dokki, Cairo, Egypt.
author
text
article
2015
eng
Metal matrix nanocomposites composed of Al-(20-x) wt.-% Al2O3 - (x) ZrO2, x=0, 1, 2 & 4, were prepared by mechanical alloying technique. The powders’ mixture was milled in a planetary ball mill up to 7h. The effect of milling time on properties of obtained powders was studied by using X-ray diffraction analysis (XRD) and transmission electron microscopy (TEM) to investigate phase composition, crystal size and morphology of the milled powders. In order to study the sinterability, the milled nanocomposite powders were cold pressed and sintered in argon atmosphere at different firing temperatures i.e. 300, 370 and 470°C for 1h. Physical properties, namely, bulk density and apparent porosity of sintered bodies were determined by Archimedes method. Phase identification and microstructure of the sintered composites were investigated by using XRD and scanning electron microscope (SEM) as well as energy dispersive spectrometer (EDS). Microhardness of sintered composite was also examined using Vickers hardness indentor. The results were discussed in terms of the effect of milling time on the properties of the prepared powders and sintered composites. The results revealed that the grain size of milled powders was about 30 nm with a noticeable presence of agglomerates. Uniform distribution of nano-sized alumina-zirconia particles in the aluminum matrix could be achieved with increasing milling time. The density of the sintered composites was affected by milling time of starting powders and firing temperature. It increased with increasing milling time and firing temperature. Microhardness of sintered bodies was found to be progressively increased with increasing of milling time of starting powders.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
88
110
https://jsrs.journals.ekb.eg/article_19948_611586de780ee9cc316ed1fc291ee538.pdf
dx.doi.org/10.21608/jsrs.2015.19948
Wireless Sensor Networks for Indoor Air Quality Monitoring
Doaa
Hassan
Electronics Research Lab., Physics Dept., Faculty of Women,
Ain Shams University, Cairo, Egypt.
author
S.
El-Ghanam
Electronics Research Lab., Physics Dept., Faculty of Women,
Ain Shams University, Cairo, Egypt.
author
A.
Abd El-Maksood
Nuclear Materials Authority, P. O. Box 530, Maadi – 11728, Cairo, Egypt.
author
A.
El-Magid
Electronics Research Lab., Physics Dept., Faculty of Women,
Ain Shams University, Cairo, Egypt.
author
F.
Soliman
Nuclear Materials Authority, P. O. Box 530, Maadi – 11728, Cairo, Egypt.
author
S.
Kamh
Electronics Research Lab., Physics Dept., Faculty of Women,
Ain Shams University, Cairo, Egypt.
author
text
article
2015
eng
Wireless Sensor Networks (WSN) has been identified as one of the most important technologies for the 21st century in the world of information technology. In the present paper, a simplified prototype self solar powered sensor node was demonstrated as a proof of concept which could be surveyed for real-time wireless detection systems. It was modeled using low cost and small-sized electronic components and wireless transceiver to serve the wireless commu-nication capabilities. The proposed system was proved to be successfully applied in detecting, transmitting, and reporting, accurately, the changes in the levels of different physical parameters. Herein, WSN was concentrated on monitoring temperature and humidity, as an example, although it can carry-out up to eight/sixteen sensors for each single node, simultaneously. Finally, all the detected data in the monitored field was transmitted wirelessly, free of any noises, to the base station, where a receiver was installed on the computer to display, analyze and save the results and changes.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
111
122
https://jsrs.journals.ekb.eg/article_19949_57b28b5114bcd28cda904e9abe18d9fe.pdf
dx.doi.org/10.21608/jsrs.2015.19949
Comparative study on the influence of rare earth ions doping in Bi0.6Sr0.4FeO3 nanomultiferroic system
M.
Ahmed
Material Science Lab. (1) Physics Department, Faculty of Science, Cairo University, Giza,
author
N.
Okasha
Physics Department, Faculty of Girls, Ain Shams University, Cairo, Egypt.
Physics Department, German University (GUC), Cairo, Egypt.
author
M.
Abdelaal
Physics Department, Faculty of Girls, Ain Shams University, Cairo, Egypt.
author
M.
Ayman
Physics Department, German University (GUC), Cairo, Egypt.
author
text
article
2015
eng
We report a comparative study of rare-earth ions substituted Bi0.6Sr0.4FeO3(BSFO) crystal for; BSFO, Bi0.57Sr0.4Y0.03FeO3, Bi0.57Sr0.4Nd0.03FeO3, Bi0.57Sr0.4Ce0.03FeO3, and Bi0.57Sr0.4La0.03FeO3, respectively. The samples were successfully synthesized using flash autocombustion reaction. X-ray diffraction analysis reveals that the crystal structure is rhombohedral and a clear hexagonal grain growth habit is seen by FESEM microstructure. The doping of BSFO improved the magnetic properties specially Y3+, Nd3+ ions. While Ce3+ improved the electrical conductivity. We argue that the addition of RE is likely to suppress the spiral spin modulation and at the same time increase the canting angle which favors the enhanced ferromagnetism.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
123
141
https://jsrs.journals.ekb.eg/article_19950_e053c7a9259d920a163507676f15b68b.pdf
dx.doi.org/10.21608/jsrs.2015.19950
Preparation of Polyaniline/polyvinylalcohol nanocomposite and study its characterization after exposure to Laser Irradiation.
F.
Barakat
Department of Spectroscopy Physics, Faculty of Girls for Art, Science and Education, Ain Shams University.
author
A.
El- Bially
Department of Spectroscopy Physics, Faculty of Girls for Art, Science and Education, Ain Shams University.
author
A.
Shabaka
Department of Spectroscopy, Physics Division, National Research Center, Giza, 12622, Egypt.
author
S.
Abd.ElMongy
Department of Spectroscopy Physics, Faculty of Girls for Art, Science and Education, Ain Shams University.
author
N.
Shahin
Department of Spectroscopy Physics, Faculty of Girls for Art, Science and Education, Ain Shams University.
author
R.
Kamal
Department of Spectroscopy Physics, Faculty of Girls for Art, Science and Education, Ain Shams University.
author
text
article
2015
eng
The present work reports(PANI/PVA) nanocomposite with different irradiation laser times were prepared. The result of transmission electron microscope (TEM) indicated that the morphology of PANI/PVA nanocomposite has a regular spherical shape. The molecular structures had been studied using Fourier Transform Infrared Spectrometer (FTIR) and the spectra of PANI/PVA nanocompositewere formed in emeraldine salt form, which consists of benzonid and quinoid. .
The conductivity measurements show that the initially electrically insulating PVA/AniHCl blend has been transformed into the electrically conducting PVA/PANI nanocomposites where the conductivity increases by increasing irradiation times. The conduction mechanism had been explained
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
142
152
https://jsrs.journals.ekb.eg/article_19951_bdb3716152d317f7e4ab3c527b64a89f.pdf
dx.doi.org/10.21608/jsrs.2015.19951
Efficiency of Egyptian mulberry water extracts in controlling nephropathy complications in diabetic rats
Heba
Barakat
Biochemistry and Nutrition Department
Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
Nora
El-Sheihk
Biochemistry and Nutrition Department
Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
Huda
Mogahed
Biochemistry and Nutrition Department
Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
text
article
2015
eng
The aim of the present study was to determine the amount and antifree radical activity of Deoxynojirimycin (DNJ) in Egyptian white and black mulberry fruits and leaves water extracts. Moreover, the study aimed to evaluate the water extracts effect of Egyptian white and black mulberry fruits and leaves, on improving hyperglycemic condition and renal complications in diabetic rats.
Seventy-two adult male albino rats Sprague-Dawley strain were equally divided into six groups: group (1) healthy control and group (2) diabetic control were given tap water by gavage tube, groups (3-6) diabetic treated with different water extracts of mulberry white fruits (WMFWE), white leaves (WMLWE), black fruits (BMFWE) and black leaves (BMLWE) (containing 50mg DNJ/kg body weight) by gavages' tube daily for 28 days. At the end of the experiment, rats were sacrificed under ether anesthesia. Blood samples were collected to separate serum; also kidneys were removed for biochemical parameters estimation.
The High Performance Liquid Chromatography (HPLC) analysis of the mulberry extracts showed that water extracts contained higher amount of DNJ than methanol or ethanol extracts. Also mulberry leaves had higher amount of DNJ than fruits and the amount of DNJ in black mulberry was more than the white one.
The treatment with mulberry water extracts effectively decreased the blood glucose level, glycated hemoglobin percentage, renal aldose reductase activity and renal protein level as compared to untreated diabetic control rats; on the other hand there was an elevation of insulin level. Also mulberry extracts ameliorate the oxidative stress status with significant elevation in nonenzymatic antioxidant with significant improvement in kidney function parameters. Based on the presented data in this study, it can be concluded that mulberry extracts possess antidiabetic effect and improving properties of nephropathy complications.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
169
187
https://jsrs.journals.ekb.eg/article_24830_adc9a4d859cbe6f2ea3ef2b5ba8ee45d.pdf
dx.doi.org/10.21608/jsrs.2015.24830
Biochemical role of phytoestrogen (Chrysin) against N-methyl nitrosourea (NMU)- induced proliferative lesions in mammary glands of postmenopausal female rat
Amal
A. El-Kirsh
Biochemistry and Nutrition Department, Faculty of Women for Arts Science and Education, Ain Shams University
author
Hanan
F. Abd El-Wahab
Biochemistry and Nutrition Department, Faculty of Women for Arts Science and Education, Ain Shams University.
author
Hala
Abd-Ellah
Zoology Department, Faculty of Women for Arts Science and Education, Ain Shams University
author
Nagwa
Y. Hassanin
Biochemistry and Nutrition Department, Faculty of Women for Arts Science and Education, Ain Shams University
author
Nehad
H. Shosha
Biochemistry and Nutrition Department, Faculty of Women for Arts Science and Education, Ain Shams University
author
text
article
2015
eng
This study aimed to investigate the role of the phytoestrogen (chrysin) in the treatment or protection of NMU-induced preneoplastic lesions in mammary glands of postmenopausal female rats. Rats (n=105) were divided into seven groups (n=15/group); group1(negative control group).Groups 2&3 (positive control groups), rats were injected intraperitoneally (i.p.) with 4 doses of NMU (75 mg/kg b.w.,once/5days) before or after oral administration of glycofurol. Groups 4 &5(treatment groups),rats received 4 doses of NMU (75 mg/kg b.w., once/5days,i. p.), left for 6 weeks then followed by 3 doses, per week, of chrysin (125 or 250 mg/kg b.w., orally; p.o), respectively, for another 6 weeks. Groups 6 & 7(protective groups), rats received 3 doses, per week, of chrysin(125 or 250 mg/kg b.w.,p.o.), for 6 weeks then followed by 4 doses of NMU (75 mg/kg b.w., once/5days, i.p.) then left for another 6 weeks. The NMU injection caused significant decrease in PLT count, lymphocytes %, Hb, MCH, MCHC, E2, TAC levels as well as GST and CAT activities. The results also showed that NMU significantly elevated WBC count, granulocytes%, monocytes %, MCV, RDW%, CRP, CEA levels and arginase activity. Either treatment or protection with chrysin modulated the adverse effects of NMU and ameliorated the change in the biochemical parameters. The biochemical observations were also confirmed by histological studies. In conclusion, phytoestrogens may relieve the severity of postmenopausal pre-cancerous disorders, especially when consumed in high dose for a while before the incidence of lesions.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
188
209
https://jsrs.journals.ekb.eg/article_24834_4fd9ddacf9d6d5008b31abca92bd9d0b.pdf
dx.doi.org/10.21608/jsrs.2015.24834
Protective effect of apricot (Prunus armeniaca L.) and its kernel against paracetamol-induced hepato-renal toxicity in rats
Mai
Abdelkawi
Biochemistry and Nutrition Department- Women’s College, Ain Shams University
author
Zakia
Abdelkader
Biochemistry and Nutrition Department- Women’s College, Ain Shams University
author
Lamiaa
A Barakat
Chemistry Department- Science College, Port Said University
author
text
article
2015
eng
This study was designed to investigate the protective effect of fresh, dried apricot and its kernel added to diet (10% and 20% w\w) on paracetamol (N-acetyl-p-aminophenol , APAP)-induced cellular toxicity in rats. Eighty male albino rats were used in this study, divided into 8 groups 10 rats each. Gp (1): set as healthy control, Gp (2) set as APAP-affected control. Gps (3-4) fed on diet supplemented with fresh apricot (10% & 20% w\w), Gps (5-6) fed on diet supplemented with dried apricot (10% & 20% w\w). Gps (7-8) fed on diet supplemented with apricot kernel (10% & 20% w\w). After 6 weeks, rats from groups (2:8) were injected with a single dose, i.p injection, of APAP (500 mg\kg body weight). After 24 h of injection, rats were sacrificed under diethyl ether anesthesia. Serum and tissue samples were collected to perform the biochemical analysis. Serum liver function tests [total protein, albumin, total bilirubin, direct and indirect bilirubin, the activities of alanine amino transferase (ALT), asparatet amino transferase (AST) and alkaline phosphatase (ALP)] were measured. Moreover, serum kidney function tests (urea, creatinine, and uric acid), and serum lipids profile were measured. Also, antioxidant status was evaluated by measuring reduced glutathione (GSH) and malondialdehyde (MDA) in liver and kidney homogenate. The results were supported with microscopic examination of liver and kidney tissues. The results of this study revealed that administration of APAP caused marked reduction in serum total protein, albumin and tissue GSH, in association with elevation of serum bilirubin, activities of AST, ALT, ALP, urea, creatinine, uric acid, lipids profile, and tissue MDA. On the other hand, supplementation of diet with fresh, dried apricots and apricot kernel had protective effect on liver and kidney tissues that was manifested by improving liver and kidney functions, antioxidant status, and lipids profile. The microscopic examination of liver and kidney tissues showed also amelioration in the appearance of cells. The protective effect of apricot and its kernel is due to their antioxidant potential that is represented by their rich content of dietary fibers, β-carotene, vitamin C, tocopherols, flavonoids, poly unsaturated fatty acids, and some polyphenols that appears to protect against reactive oxygen species (ROS) and consequently APAP toxicity.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
210
231
https://jsrs.journals.ekb.eg/article_24839_0729aea69db539a7d74da4e99b3cab22.pdf
dx.doi.org/10.21608/jsrs.2015.24839
Cooperation of Nicotinamide with Mesenchymal Stem Cells to Control Diabetes Mellitus-Induced by Streptozotocin in Rats
Nora,
El-Sheikh
Biochemistry and Nutrition Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
Eman,
Mohamad
Biochemistry and Nutrition Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
Hanaa,
Abdel-Fattah
Biochemistry and Nutrition Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
Mervat
El-Ansary
Pathology Department, Faculty of Medicine, Cairo University
author
text
article
2015
eng
The main objective of this work is to assess the role of nicotinamide in protecting β-cells of rat’s pancreas after STZ injection and to study the therapeutic potency of bone marrow mesenchymal stem cells in STZ-induced diabetic rats. Ten male albino rats were sacrificed and used for isolation and differentiation of MSCs into insulin producing cells within 4 weeks. Fifty male albino rats were divided into 5 groups. Group (1): normal control. The other groups were injected with STZ 50 mg/kg b.w. for induction of diabetes. Group (2): diabetic control, group (3): diabetic rats received oral nicotinamide (NIC) 100 mg/kg b.w. daily (NIC group), group (4): diabetic rats injected subcutaneously with differentiated MSCs 5x106 cells per rat (MSCs group), group (5): diabetic rats injected subcutaneously with differentiated MSCs 5x106 cells per rat and received oral NIC 100 mg/kg b.w. daily (MSCs + NIC group) the treatment continued for 4 weeks. The results indicated that injection with MSCs and administration of oral NIC ameliorate the glucose homeostasis by decreasing blood glucose and increasing insulin and C-peptide levels, improving antioxidant status by decreasing serum MDA level and increasing the activity of (serum TOC, liver SOD and GPX), serum lipid profile TC, TAGs, LDL-C and VLDL-C were deceased while HDL-C was increased while using both of MSCs and NIC caused more improvement which was evidenced in the histopathological examination of pancreatic cells. In conclusion: treatment with nicotinamide improves the diabetic state of rats as nicotinamide is believed to have anti-hyperglycemic and anti-oxidant properties. MSCs were successfully differentiated into numerous numbers of β-cells and injection with 5×106 MSCs clearly support pancreas tissue repair.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
250
268
https://jsrs.journals.ekb.eg/article_24858_dd9420a8d96275d00b84e299e4c4cf4d.pdf
dx.doi.org/10.21608/jsrs.2015.24858
Evaluation of consuming fresh pineapple juice (Ananas Comosus) or bromelain on acetic acid-induced ulcerative colitis in rats
Fatma
Khalil
Biochemistry and Nutrition Department, Women's College, Ain Shams University, Cairo, Egypt
author
Nora
El-Sheikh
Biochemistry and Nutrition Department, Women's College, Ain Shams University, Cairo, Egypt
author
Hadeer
M. Maria
Biochemistry and Nutrition Department, Women's College, Ain Shams University, Cairo, Egypt
author
text
article
2015
eng
This study aimsto evaluate the efficacy of fresh pineapple juice and bromelain consumption on acetic acid-induced ulcerative colitis in rats. Furthermore the study aims to determine the amount of bromelain in fresh pineapple juice by HPLC as well as some of the bioactive constituents of fresh pineapple juice. Sixty male albino rats were divided into six groups; each group consisted of 10 rats. Group (1) served as normal control (Healthy) and group (4) served as positive control (Colitis). Healthy rats of group (2) and colitis rats of group (5) treated with 0.5ml fresh pineapple juice/100g body weight by stomach tube as well as healthy rats of group (3) and colitis rats of group (6) treated with 0.5ml bromelain/100g body weight daily using stomach tube. The results of chemical analysis of pineapple revealed that each 100ml of the fresh prepared pineapple juice contains 425±3.00mg as gallic acid equivalent (GAE) for total phenols, 584±4.00mg as catechin equivalent (CE) for total flavonoids, 25±1.00 mg for ascorbic acid and 57±1.00% as ascorbic acid equivalent (AAE) for total antioxidant capacity. Induction of ulcerative colitis by acetic acid (0.25ml of 16% acetic acid/ 100g body weight) markedly increased the oxidative stress which caused significant reduction in nonenzymatic antioxidant such as blood reduced glutathione (GSH), enzymatic antioxidants as serum catalase (CAT) and colon superoxide dismutase (SOD) activities, also resulted in increased lipid peroxidation (LPO) of membranes as colon malondialdehyde (MDA) was significantly increased. Furthermore, serum inflammatory marker levels as tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) activity and C-reactive protein (CRP) were significantly increased in colitis rats (p>0.05). While treatment of colitis rats by fresh pineapple juice or bromelain ameliorated the oxidative stress status and decreased inflammatory markers which alleviated the colitis. The microscopic examination of colon sections illustrated the modulating effect of both fresh pineapple juice and bromelain on colon cells. In conclusion, fresh pineapple juice had a better effect than bromelain as its high content of antioxidants as well as bromelain.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
269
282
https://jsrs.journals.ekb.eg/article_24862_bceaa3c385d089cc22905446004b3867.pdf
dx.doi.org/10.21608/jsrs.2015.24862
Therapeutic Roles of Silymarin or/and Taurine on Nonalcoholic Fatty Liver Disease Associated with Metabolic Syndrome in Rats
Zahran,
M
Zoology Department, Faculty of Women for Arts, Science and Education , Ain Shams University
author
Shahin,
I
Zoology Department, Faculty of Women for Arts, Science and Education , Ain Shams University
author
Kelada,
A
Zoology Department, Faculty of Women for Arts, Science and Education , Ain Shams University
author
Heibashy,
M.I
Zoology Department, Faculty of Women for Arts, Science and Education , Ain Shams University
author
text
article
2015
eng
Non-alcoholic fatty liver disease (NAFLD) represents one of the most common liver diseases. It is strongly associated with obesity and insulin resistance and thought to be parameters of the metabolic syndrome. NAFLD can progress to non-alcoholic steatohepatitis then to cirrhosis and liver failure. This study aimed to investigate whether silymarin or/and taurine can improve non-alcoholic fatty liver in an animal model and whether this therapeutic approach can result amelioration in carbohydrates profile (serum glucose, insulin, insulin resistance index and hepatic glycogen), lipids profile (serum cholesterol, triglycerides, free fatty acids, leptin and adiponectin as well as hepatic total lipids & cholesterol), liver function profile (serum aspartate transaminase, alanine transaminase, total protein, albumin and haptoglobin) and the cytokines profile (serum tumor necrosis factor-α, interleukin-1ß and interleukin-6). The obtained results revealed a significant (p<0.001) increase in carbohydrates profile (glucose, insulin, insulin resistance index & hepatic glycogen) in NAFLD rats than those in their control ones. Similary, lipid parameters (serum cholesterol, triglycerides, free fatty acids and leptin as well as hepatic total lipids & cholesterol) and liver function tests (serum aspartate transaminase, alanine transaminase and haptoglobin)were significantly (p<0.001) elevated in NAFLD rats compared with their corresponding control group. On the other hand, induction of NAFLD to rats caused a significant (p<0.001) decrease in adiponectin level with a remarkable decrease in serum total protein and albumin.
A considerable (p<0.001) elevation were occurred in all cytokines parameters (serum tumor necrosis factor-α, interleukin-1ß and interleukin-6) in NAFLD rats group compared with their corresponding control group.
When, NAFLD rats group was treated with silymarin or/and taurine, a considerable amelioration effects in all previous studied parameters were pronounced dependent on certain mechanisms and time of treatment.
In conclusion, silymarin or/and taurine reduced metabolic abnormalities associated with NAFLD via inhibition the oxidative stress, increment in the stabilization of mitochondrial membrane, reduction the lipid accumulation in the liver, enhancement in the endoplasmic reticulum (ER) and improving insulin resistance. Overall, silymarin and taurine may be considered as promising and novel therapies for the treatment of NAFLD.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
283
310
https://jsrs.journals.ekb.eg/article_24867_481c18a93fe5792891f105824f42426d.pdf
dx.doi.org/10.21608/jsrs.2015.24867
Tamoxifen- Induced Chromosomal Aberrations in Pregnant Female Rats
Sara
Fawzy
Zoology Dept., Faculty of Women for Arts, Science and Education, Ain -Shams University
author
Ramadan
M. Ali
Zoology Dept., Faculty of Women for Arts, Science and Education, Ain -Shams University
author
Mervat
Labib
Zoology Dept., Faculty of Women for Arts, Science and Education, Ain -Shams University
author
Mohamed
Rashed
Genetics Dept., Faculty of Agriculture, Ain-Shams University
author
text
article
2015
eng
Tamoxifen is a non-steroidal, selective estrogen receptor modulator (SERM) used in the treatment of all the stages of breast cancer patients at all ages. Recent evidences showed that tamoxifen could induce cancers which might be a consequent result for chromosomal aberrations in rats. For investigating the chromosomal aberrations induced by tamoxifen treatment, pregnant female rats (four rats per treatment) received tamoxifen orally at dose 0 and 20 mg/ kg b. wt. at different periods. Animals were injected (ip.) with colchicine at 1.5 hr prior sacrifice. Rats were sacrificed 24hr after last treatment. bone marrow cells where collected, then the cells were prepared for karyotype evaluation. 50 well spread metaphase plates were examined per animal. Tamoxifen induced significant increases in the frequencies of structural chromosomal aberrations, like gaps, Centric fragments, dicentirc chromosomes, centric separation and centric fusions in the bone marrow metaphases. However, tamoxifen did not elevate the averages of numerical chromosomal aberrations than the averages of control level. Moreover, a significant increase in the mitotic activity of the bone marrow cells was observed after tamoxifen treatment. The present study proved the clastogenic and the spindle poisoning action of tamoxifen. Consequently, risks against benefits should be carefully evaluated when tamoxifen is used as a therapy of choice on humans.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
311
324
https://jsrs.journals.ekb.eg/article_24868_80d3a2081a06d814eae4022e64f9575f.pdf
dx.doi.org/10.21608/jsrs.2015.24868
Galantamine bioactivity improvement in rat brain using two novel nanodrug delivery systems as therapy for Alzheimer's disease
Sara
Kamal
Zoology department, Women’s College for Arts, Science and Education – Ain Shams University
author
Sanaa
R.Wahba
Zoology department, Women’s College for Arts, Science and Education – Ain Shams University
author
Atef
Darwish
Chemistry department, Faculty of Science, Ain Shams University
author
text
article
2015
eng
Reminyl is one of the most common drugs presently used for treatment of mild to moderate Alzheimer. The present study is an attempt to investigate the influence of presenting two innovative nano-engineered drug carriers (Ce/Ca-HAp& CMCS/Ce/Ca-HAp) as carriers for Rem in Alz therapy. A total of 86 adult female albino Wistar rats were randomly assigned to the following groups: Control group (C) of 8 rats given saline; Reminyl group (Rem) of 8 rats treated with Rem; Alzheimer’s group (Alz) of 16 ovariectomized animals inoculated orally with AlCl3 (17mg/Kg b.wt/day) for 2 months after 6 weeks of surgical operation; Alzheimer’s disease-induced rats treated (i.p) with Rem (2.5mg/Kg b.wt/day); Alzheimer’s disease-induced rats treated (i.p) with Rem coated by Ce/Ca-HAp (2.5mg/Kg b.wt/day) and Alzheimer’s disease-induced rats treated (i.p) with Rem coated by CMCS/Ce/Ca-HAp (2.5mg/Kg b.wt/day). After 2 and 4 weeks animals were sacrificed by ether inhalation anesthesia where brains were removed and processed for histological analysis by Hx&E and biochemical analysis for measuring GSH, SOD, CAT and CytoP450reductase levels. Histological and biochemical alterations designated in Rem treated rat brains were ameliorated following the use of Rem coated by Ce/Ca-HAp and not with Rem coated by CMCS/Ce/Ca-HAp. Initiation of new nano drug delivery systems may attribute in delivery of therapeutic drug to the site of action and overcome drawbacks of the drug alone.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
325
336
https://jsrs.journals.ekb.eg/article_24870_2e24fb1052cb174b2e7de7dd54c1fe51.pdf
dx.doi.org/10.21608/jsrs.2015.24870
Partial and Total Substitution of Dietary Fishmeal by Conventional or Genetically Modified Soybean Meal with or without Formic Acid Supplementation for Oreochromis niloticus Fingerlings
Eman
Mohammady
Fish Nutrition Laboratory, National Institute of Oceanography and Fisheries, Fish Research Station, El-Qanater El-Khayria.
author
Ashraf
A-S Goda
Fish Nutrition Laboratory, National Institute of Oceanography and Fisheries, Fish Research Station, El-Qanater El-Khayria.
author
Ramadan
Mohamed
Zoology Department, Women’s College for Arts, Science and Education, Ain Shams University
author
Mohamed
Mohamed
Fish Nutrition Laboratory, National Institute of Oceanography and Fisheries, Fish Research Station, El-Qanater El-Khayria.
author
text
article
2015
eng
A feeding trial was conducted to reduce the cost of diet by using two sources of soybean meal (conventional or genetically modified) instead of the expensive commercial fishmeal (FM). In the present study, commercial FM was substituted by partial (50%) or total (100%) soybean. Diets were supplemented with formic acid (FA) at level of 0 or 10 ml/kg to investigate the growth performance and feed utilization of Oreochromis niloticus. The experiment was conducted with 360 Nile tilapia fingerlings (with initial weight, 22.15 ± 2.70 g). Nine isonitrogenous 25% crude protein and isocaloric 19.28 MJ/kg gross energy experimental diets were formulated. Over the 10-weeks feeding period, formic acid supplementation elevated the growth performance and feed utilization for fish fed either 50% conventional (C-SBM50) or 50% genetically modified soybean meal (GM-SBM50). Serum ALT, AST, glucose and triglyceride values were lower in fish fed the control diet and conventional soybean in comparison with those fed genetically modified soybean meal. No obvious changes were found in micronucleus or in nuclear abnormalities for all diets compared with the control diet. FA supplementation improves the growth performance, feed utilization and biological abdominal parameters in fish fed either C-SBM50 or GM-SBM50. In spite of that, genetically modified soybean elevated the levels of ALT, AST, glucose and triglyceride. These results draw our attention to the important use of organic acids in fish diets to improve the growth performance and feed utilization. As regarding the genetically modified soybean, it needs more investigation to evaluate their effect on feeding trial on fish.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
337
359
https://jsrs.journals.ekb.eg/article_24872_bf378ec425e60e6bc75772a55924c42c.pdf
dx.doi.org/10.21608/jsrs.2015.24872
The Effect of "Cleome droserifolia" Extract Versus Stem Cells Therapy on The Changes Induced by ʎ-Cyhalothrin in Male Albino Rats
Nura
Al-Zail
Department of Zoology, Faculty of Science, Omar AL-Moukhtar University, El-Beida, Libya
author
Magda
H. Afifi
Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University
author
Nora
M. Shaheen
Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University
author
Hala
Abd-Ellah
Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University
author
Hala
Metwally
Department of Clinical Pathology, Faculty of Medicine, Cairo University.
author
text
article
2015
eng
ʎ-cyhalothrin (LCT) is pyrethroid insecticide that is used worldwide for pest control in agriculture and household use. Cleome droserifolia extract (CDE) is a potential antioxidant protecting cells from oxidative stress. Mesenchymal stem cells (MSCs) have the capacity to generate multiple distinct cell lineages. The present study investigates the protective and therapeutic effect of CDE and MSCs, separately on LCT-induced changes in male rats. Seventy adult male albino rats were divided into seven groups: group I: served as control; group II: received LCT i.p. only (6.2 mg/kg b.wt.); group III: received CDE only (100 mg/kg b.wt., p.o.) for eight weeks; group IV: received CDE as a protective agent daily for eight weeks, then followed by the administration of LCT (i.p.) three times a week for two weeks; group V: exposed to LCT (i.p.) three times a week for two weeks, then treated with the CDE daily for 8 weeks; group VI: rats injected (i.v.) with a single dose of MSCs (1x106 cells/cm2 saline), then received dose of LCT (i.p.) three times a week for two weeks and group VII: rats received dose of LCT (i.p.) three times a week for two weeks, then injected (i.v.) with a single dose of MSCs. Results showed that, LCT caused significant reduction in the body and testis weight, and markedly impaired sperm quality (a count, viability, motility and abnormality). Also, LCT elicited significant declines in serum testosterone, whereas, serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) were significantly increased. Compared to LCT-treated animals, CDE in the protective group markedly restored the alteration of body and testis weights, sperm indices and sexual hormones. However, CDE in the curative group was found to be less effective in restoring LCT induced morphological and biochemical alterations. Transplantation of MSCs as being a therapy after LCT intoxication showed significant improvement in the activity of all parameters rather than their protective effect which showed minimal protection against LCT. In conclusion, data of this study revealed that the protective by CDE and therapeutic by MSCs are more effective than therapeutic by CDE and protective by MSCs in ameliorating LCT-induced testicular damage and improvement of male fertility and reproductive functions.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
360
378
https://jsrs.journals.ekb.eg/article_24878_08e2a99d6c06c5fd3df10bf49091f422.pdf
dx.doi.org/10.21608/jsrs.2015.24878
The effect of L–carnitine on gentamicin-induced nephrotoxicity and associated anaemia in adult male albino rats
Nefissa
Meky
Zoology Department, Faculty of Science, Ain Shams University.
author
Mohamed
Heibashy
Biological Applications Department Nuclear Research Centre, Atomic Energy Authority
author
Ola
Mahmoud
Departments of Hematology, Theodor Bilharz Research Institute, Cairo, Egypt
author
Heba
Youssef
Zoology Department, Women’s College, Ain Shams University.
author
text
article
2015
eng
This study was conducted to evaluate the effect of L-carnitineon gentamicin-induced nephrotoxicity and anaemia in adult male albino rats. A control group (saline, group I, n = 21) was compared with rats administrated 80 mg/kg gentamicin, once daily for 10 days (groups II, n = 49). After 10 days 7 rats from each group were sacrificed for investigation. The remaining of normal control rats was served as normal control group (Group 1) (14 rats), while 42 nephrotoxic rats subdivide in to: Subgroup 2 (control 2): Nephrotoxic rats (14 rats). Subgroup 3: Nephrotoxic rats were injected intraperitoneal with L-carnitine (300 mg/kg/day) for 15 and 30 days (14 rats). Subgroup 4: Nephrotoxic rats were injected intraperitoneal with L-carnitine (600 mg/kg/day) for 15and30 days (14 rats). At the end of each experiment period, 7 rats from each groups were sacrificed. The effect of L-carnitine (group III and IV) was compared. The activities of biochemical parameters [urea, creatinine, β2-microglobulin, potassium (K), total oxidant status (TOS)] and [iron (Fe), total iron binding capacity (TIBC) and ferritin] increased in nephrotoxic rats, while total protein, sodium (Na) and total antioxidant status (TAS) decreased and in haematological parameters osmotic fragility increased but haemoglobin and red blood cells (RBCs) decreased in nephrotoxic rats. Administration of L-carnitine improved alterations of biochemical and haematological parameters. In conclusion, this study demonstrated that treatment with L-carnitine attenuated the biochemical and haematological alterations induced by gentamicin and identifies new areas of research for development of better therapeutic agents for kidney and better dose.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
379
400
https://jsrs.journals.ekb.eg/article_24885_070bb9dfbbcf237ee3b6da5d312ad305.pdf
dx.doi.org/10.21608/jsrs.2015.24885
Role of Cytokines as Biomarkers in Arthritic Rats and the Efficiency of Diclofenac Therapy in the Presence of some Antioxidants
Hammad,
A
Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University.
author
F.
El-Negamy,
Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University.
author
Shahin,
I
Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University.
author
Hassanin,
S.
Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University.
author
Heibashy,
I
Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University.
author
text
article
2015
eng
Rheumatoid arthritis (RA) is an autoimmune disease accompanied by hyperplasia of the cartilage caused by infiltration of inflammatory cells and resulting in joint damage. Diclofenac is one of the most prospective and commercially successful drugs in the family of nonsteroidal anti-inflammatory drugs (NSAIDs) used for the treatment of rheumatoid arthritis. Curcumin, a member of the curcuminoid family of compounds has antioxidant and anticarcinogenic activities which have been attributed to its hydroxyl and methoxy groups. Quercetin is categorized as a flavonol has been shown to exert antimicrobial, antiviral, anti-inflammatory and antioxidant activities. Curcumin and quercetin are antioxidant molecules with anti-proliferative, anti-inflammatory and immunosuppressive activities. The objective of this study was to investigate the inhibitory activity of these three agents on inflammatory aspects of arthritis. This experiment was carried out on adult male albino rats and included two experiment, the first one aimed to show the changes occurred in some physiological and biochemical parameters in serum and tissue as a result of arthritis induction which was induced by injection 150 μl pristine. In the second experiment, five comparisons were made between normal control rats and another four animal groups suffering from arthritis. The 1st group of them was injected intramuscularity with diclofenac (5mg/100g b.wt) for 1, 2 and 4 weeks. The 2nd group was treated with diclofenac and administrated orally with 100 mg curcumin / 100 g b.wt. for 1, 2 and 4 weeks. The 3rd animal group was treated with diclofenac and administrated orally 100 mg quercetin /100 g b.wt. for the same pervious intervals. The 4th arthritic animal group treated with diclofenac, curcumin and quercetin as described before for the same times. In this study, the obtained results revealed that induction of arthritis in rats caused a significant elevation in the levels of C-reactive protein (CRP), interleukin-1α (rat IL-1α), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Also, in arthriric rats, serum total antioxidant capacity (TAC) decreased while total oxidative capacity (TOC), total antioxidant, total nitric oxide (TNO) and resistin increased. In joint cartilage of arthritic rats, prostaglandin (PGE2), cyclooxygenase (COX-2), malondialdehyde (MDA) and resistin levels were remarkably increased compared to those normal control animals. All previous parameters were corrected after the administration of diclofenac with curcumin or/and quercetin depending on the time of treatment (1, 2 & 4 weeks). The data were discussed according to available obtained researches.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
401
419
https://jsrs.journals.ekb.eg/article_24892_2852175fa66a8695cca22d2bc020b14d.pdf
dx.doi.org/10.21608/jsrs.2015.24892
Evaluation of the Efficacy of Autologous Bone Marrow Stem Cell Transplantation in Type 1 Diabetes Mellitus.
Eman
Sherif
Zoology Department, Women`s College, Ain Shams University.
*Surgery Medicine, Ain Shams University.
author
Serag El Din
S
Zoology Department, Women`s College, Ain Shams University.
*Surgery Medicine, Ain Shams University.
author
Magda
Hassanin
Zoology Department, Women`s College, Ain Shams University.
*Surgery Medicine, Ain Shams University.
author
Khaled
Makboul
Zoology Department, Women`s College, Ain Shams University.
*Surgery Medicine, Ain Shams University.
author
Alaa
Ismail
Zoology Department, Women`s College, Ain Shams University.
*Surgery Medicine, Ain Shams University.
author
text
article
2015
eng
Diabetes mellitus (DM) is characterized by hyperglycaemia that is often associated with long- term complication, including microvascular (retinopathy, nephropathy, and neuropathy) macro vascular damage. The present study was designed to evaluate the possible role of autologous bone marrow stem cell transplantation for cases of type 1 DM, which could differentiate into insulin- producing β cells and its role in modulating the immune response from T helper 1 to T helper 2. This study was conducted on 10 cases of autoimmune type 1 diabetes mellitus, both males and females. They were selected according to inclusion and exclusion criteria. We observed that 70% of studied subjects decreased in their insulin requirements. Fasting and postprandial blood glucose significantly decreased after transplantation, while levels of C- peptide were significantly increased at the end of 9 months of autologous bone marrow- derived stem cell transplantation (SCT). But glycated haemoglobin significantly decreased after transplantation. No side effects were noted in liver and kidney functions. Our observations indicated that SCT is a safe and effective modality of treatment to improve β- cell function in patients with T1DM.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
420
437
https://jsrs.journals.ekb.eg/article_24894_28bbeb779ebc5fa97221410c2c1d4867.pdf
dx.doi.org/10.21608/jsrs.2015.24894
Effect of Salmon Fish on Lipid Profile of Male and Female Albino Rats
Serag El Din,
S
Zoology Department, Women's College for Arts, Science and Education, Ain Shams University
author
Batta,
Abd El Azim
Zoology Department, Women's College for Arts, Science and Education, Ain Shams University
author
Abd El Fattah,
N
Zoology Department, Women's College for Arts, Science and Education, Ain Shams University
author
text
article
2015
eng
Increased serum lipid levels are associated with the increased risk of many metabolic disorders including cardio vascular disease (CVD), obesity and diabetes mellitus. The objective of the current study was to determine whether feeding salmon diet with omega-3 polyunsaturated fatty acids (n-3 PUFAs) will alter serum lipid profile in male and female rats after three months of feeding. Although many studies have focused on the role of salmon fish on human health the results remain controversial. Consequently, the question of whether or not salmon fish are beneficial or harmful to lipid profile remains unresolved. Male and female Wistar albino rats were used in the present study. Each sex was randomly divided into two groups (n= 20 per group).Control group: fed on the rodent diet AIN-93G which was recommended by the American Institute of Nutrition for growth, pregnancy and lactation. Salmon diet treated group: each rat was fed individually on cooked salmon fish diet 0.34 ـــ 0.69 gm/ rat which is equivalent to 200 gm / 70 kg human body weight then were all given AIN-93G diet ad-libitumfor three months. At the end of the experimental period the results showed that compared to the control group salmon diet significantly decreased serum levels of total cholesterol (TC) and triglycerides (TG) and significantly increased serum high-density lipoprotein (HDL-C) level however no effects were detected on serum low-density lipoprotein (LDL-C), glucose, insulin and body weight in male rats. Also in female rats salmon diet significantly decreased serum levels of TC and TG but no effect on HDL-C, LDL-C, glucose, insulin and body weight was observed. These results suggest that salmon meal play a protective role from cardio vascular disease (CVD) by decreasing lipid profile.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
438
457
https://jsrs.journals.ekb.eg/article_24897_63fbcb5fef7321dfc821313d1bda70bf.pdf
dx.doi.org/10.21608/jsrs.2015.24897
The Ameliorative Effect of Propolis Extract (bee glue) Against Oxidative Damage Induced by Methotrexate in Rats
Nourhan
EL-Rahmany
Biochemistry and Nutrition Department,
Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
Fatma
Khalil
Biochemistry and Nutrition Department,
Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
Amal
Ahmed
Biochemistry and Nutrition Department,
Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
Enas
Kamel
Biochemistry and Nutrition Department,
Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
author
text
article
2015
eng
Methotrexate (MTX) is an anti-folate used to treat cancer and some inflammatory diseases. The efficacy of MTX is often limited by its severe toxicity. Propolis is one of the most significant bee products that has an important role in balancing antioxidant systems and has an anti-peroxidant effect on several tissues. The present study was conducted to investigate the ameliorative effect of propolis against the methotrexate induced oxidative damage on blood, liver and kidney in rats. A total of one hundred and twenty male Wistar albino rats of mean body weights 90 ± 5 g were divided into 5 groups. Rats were administered their respective doses of propolis and/or MTX for 3, 6 and 9 weeks intervals. Control groups (G1 and G2), propolis group (G3), methotrexate group (G4) and methotrexate and propolis co-administered group (G5).The results showed that the MTX significant reduced hemoglobin concentration, hematocrit %, MCHC value, RBCs, WBCs and platelets count and significantly increased MCV and lymphocytes %. Moreover, it caused a significant increase in MDA level and significant decrease in GSH concentration in liver tissue as compared to normal control group (G1) in a time dependent manner. MTX administration also caused significant increase in serum AST, ALT and ALP activities in a time dependent manner, but a significant increase in total bilirubin only in 9 weeks as compared to normal control (G1). On the other hand, MTX impaired kidney function as reflected by a significant increase in serum urea and creatinine levels and decrease in serum uric acid level as compared to normal control group. Results suggest that administration of propolis extract (G5) help reduce the deleterious effects due to MTX injection in a time dependent manner, whereas, administration for 9 weeks offers better alleviation over 6 or 3 weeks. Data showed that long term administration of MTX for 9 weeks produce maximum damage over 6 or 3 weeks. Propolis extract administration also recovered the structural and functional integrity of the hepatic cells.
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
232
249
https://jsrs.journals.ekb.eg/article_24900_32a448c5d001dfe8f9f167b567d856b4.pdf
dx.doi.org/10.21608/jsrs.2015.24900
Preparation and characterization of a bioactive glass/agarose/gelatin nanocomposite scaffold for bone engineering
Manar
Ahmed
Biomaterials Department, National Research Center, 33 El-Behooth St., Dokki, Giza, Egypt
author
A.
Ibrahim
Physics Departement, University Collage of Women (Arts, Science, and Education), Ain-Shams University
author
Bothaina
Abd El-Hadya
Biomaterials Department, National Research Center, 33 El-Behooth St., Dokki, Giza, Egypt
author
Ashraf
Ali
Inorganic Chemistry Department, National Research Center, 33 El-Bohooth St., Dokki 12622, Cairo, Egypt
author
Abeer
El-kadya
Biomaterials Department, National Research Center, 33 El-Behooth St., Dokki, Giza, Egypt
author
text
article
2015
eng
A bioactive glass/agarose/gelatin nanocomposite scaffold was prepared for bone engineering application. The scaffold was characterized by Scaning Electron Microscopy (SEM), Fourier infrared spectra (FTIR), andThermogravimetric Aanalysis(TGA). SEM micrographs showed that the scaffold had a well-interconnected macroporous structure. TGA indicated that the glass content in the scaffold was 57.12% which is close to the predecided one (60 wt%). The porosity percentage of the scaffold was measured by mercury porosimetry which showed that the scaffold has high porosity percentage (71.30%). In vitro bioactivity evaluation was carried out by immersion of the scaffold in simulated body fluid (SBF) for 2 and 4 weeks. Results showed that the scaffold was able to induce an apatite layer on its surface as verified by SEM, FTIR and Thin Film X-ray (TXRD).
Journal of Scientific Research in Science
Ain Shams University, Faculty of Women for Arts, Science and Education
2356-8364
32
v.
part 2
no.
2015
153
168
https://jsrs.journals.ekb.eg/article_24905_a0722c3d1471715c247f8dcc62de694b.pdf
dx.doi.org/10.21608/jsrs.2015.24905