Role of Rutin on Acetaminophine Induced Hepatotoxicity in Adult Male Rats

Document Type : Original Article

Authors

1 Zoology Department, Women’s College for Arts, Science and Education – Ain Shams University, Egypt

2 2Molecular Biology and Tissue Culture, Faculty of Medicine, Medical Research Center, Ain Shams University. Cairo, Egypt

3 Zoology Department, Faculty of Science, Omar AL-Moukhtar University.EL-Beida,Libya.

Abstract

The present study was designed to investigate the effect of rutin on over dose acetaminophen –induced hepatotoxicity with overdose in rats. Adult male albino rats were divided into four groups. Group 1 served as control and group2: rats received rutin .Hepatotoxicity where received induced in groups 3&4,where group 3 rats were given acetaminophen (750mg/kg b.w) every 72h over a period of 21 days then left for 30 days without any treatment .Group 4: rats receiving dose of acetaminophen for 21 days (750mg/kg b.w) every 72 h then treated orally with rutin 25mg/kg b.w daily for 30 day.
A significant increase in the activities of liver markers enzymes, serum aminotransferase, γ-glutamyl transpeptidase , lipid peroxidation (MDA)  and lipid profile and a decrease in the activities of superoxide dismutase(SOD).Rutin supplementation after acetaminophen treatment significantly decreased the levels of liver markers enzymes, lipid profile was observed and MDA while, significant elevated in the activity of liver SOD was  recorded when compared with control group .
 
 

Keywords

Journal of Scientific Research in Science
Volume 34, part1
September 2017
Pages 59-65

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