Kamal, S., Wahba, S., Mostafa, A. (2020). Therapeutic role of MSCs-derived exosomes for Alzheimer's disease. Journal of Scientific Research in Science, 37(Part 2 (Biological Sciences)), 47-59. doi: 10.21608/jsrs.2020.129933
Sara Mostafa Kamal; Sanaa M.R. Wahba; Aliaa R.H. Mostafa. "Therapeutic role of MSCs-derived exosomes for Alzheimer's disease". Journal of Scientific Research in Science, 37, Part 2 (Biological Sciences), 2020, 47-59. doi: 10.21608/jsrs.2020.129933
Kamal, S., Wahba, S., Mostafa, A. (2020). 'Therapeutic role of MSCs-derived exosomes for Alzheimer's disease', Journal of Scientific Research in Science, 37(Part 2 (Biological Sciences)), pp. 47-59. doi: 10.21608/jsrs.2020.129933
Kamal, S., Wahba, S., Mostafa, A. Therapeutic role of MSCs-derived exosomes for Alzheimer's disease. Journal of Scientific Research in Science, 2020; 37(Part 2 (Biological Sciences)): 47-59. doi: 10.21608/jsrs.2020.129933
Therapeutic role of MSCs-derived exosomes for Alzheimer's disease
1Zoology department; Faculty of Women for Arts, Science and Education – Ain Shams University.
2Zoology department, Faculty of Women for Arts, Science and Education, Ain Shams University.
3Basic Science department, Faculty of Oral and Dental Medicine, Future University.
Abstract
The discovery of mesenchymal stem cell-derived exosomes (MSCs-derived exosomes) has shed a new light in the development of disease-modifying treatments for Alzheimer (AD). The present study is an attempt to investigate the influence of these extracellular vesicles (exosomes) in Alz therapy. A total of 38 adult female albino Wistar rats were randomly assigned to the following groups: Control group (C) of 8 rats given saline; Alzheimer’s group (Alz) of 15 ovariectomized animals inoculated orally with AlCl3 (17mg/Kg b.wt/day) for 2 months after 6 weeks of surgical operation and 15 Alzheimer’s disease-induced rats treated (i.v) with (107 MSCs-derived exosomes/rat/week). After 2 and 4 weeks animals were sacrificed by ether inhalation anesthesia where brains were removed and processed for histological investigation by Hx&E and biochemical analysis for measuring β-Amyloid 1-42 and Brain derived neurotrophic factor (BDNF) levels.
[1] M.M. Said, G.A. Elmenoufy, "The possible neurotherapeutic effects of Mesenchymal stem cells on AlCl3-inducedAlzheimer's disease in adult albino rats", OSR-JPBS (2015) 10(5):33-40.
[2] Y. Tang, M.W. Lutz, Y.Xing, "A systems-based model of Alzheimer's disease",Alzheimers Dement.(2019)15(1):168-171.
[3] F. Kametani, M. Hasegawa,"Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's disease",Front Neurosci.(2018)12: 12-25.
[4] N.R. Naidu, S. Bhat, U. Dsouza,"Effect of long term administration of aluminum chloride on oxidative stress and acetylcholinesterase activity in rat brains", IJPBS(2013) 3(1):616-622.
[5] S.M.R. Wahba, A.S. Darwish, S.M. Kamal, "Ceria-containing uncoated and coated hydroxyapatite-based galantaminenanocomposites for formidable treatment of Alzheimer’s disease in ovariectomized albino-rat model", Mater Sci Eng C Mater Biol Appl.(2016) 65:151-163.
[6] S.M. Kamal, 2015 M.Sc. Thesis "Galantamine bioactivity improvement in rat brain using various novel nano-drug delivery systems as therapy for Alzheimer's disease", (Women's college for Arts, Sc. and Edu., Ain Shams University).
[7] G. Li, R. Bi, D. Zhang, M. Xu, R. Luo, D. Wang, Y. Fang, T. Li, C. Zhang, Y. Yao, "Female-specific effect of the BDNF gene on Alzheimer's disease", Neuro Biol Aging. (2017) 53(192): 11-19.
[8] M.L. Giuffrida, A. Copani, E. Rizzarelli, "A promising connection between BDNF and Alzheimer’s disease", Aging (Albany NY), (2018) 10(8): 1791–1792.
[11] A. Luarte, L.F. Bátiz, U. Wyneken,C. Lafourcade, "Potential therapies by stem cell-derived exosomes in CNS diseases: focusing on the neurogenic niche", Stem Cells Int., (2016) ID: 5736059.
[12] Z. Cai, M. Xiao,S.H. Quazi,Z. Ke, "Exosomes: a novel therapeutic target for Alzheimer’s disease?", Neural Regen. Res. (2018) 13(5):930-935.
[13] L.C. Liew, T. Katsuda, L. Gailhouste, H. Nakagama, T. Ochiya, "Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer’s disease", Int. Immunol. (2017) 29(1):11-19.
[18] E. GATTI, N.D. VIRGILIO, M. S. MAGLI, “PREDIERI, INTEGRATING SENSORY ANALYSIS AND HEDONIC EVALUATION FOR APPLE QUALITY ASSESSMENT” J. Food Qual.(2011) 34:126–132.
[19] A. Othman, R. Mubarak, M. Sameer, D. Sabry, “Fibroblast growth factor-6 enhances CDK2 and MAKT expression in microvesicles derived from human stem cells extracted from exfoliated deciduous teeth” F1000. (2019) 7:610-622.
[21] B.A. Berihu, M. Afwerk, Y.G. Debeb, A. Gebreslassie, "Review on Histological and Functional Effect of Aluminium Chloride on Cerebral Cortex of the Brain", IJPSR (2015) 6(8): 1105-1116.
[25] L. Jiang, H. Dong, H. Cao, X. Ji, S. Luan, J. Liu, "Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer’s Disease", Med Sci Monit.(2019) 25: 3329–3335.
[1] M.M. Said, G.A. Elmenoufy, "The possible neurotherapeutic effects of Mesenchymal stem cells on AlCl3-inducedAlzheimer's disease in adult albino rats", OSR-JPBS (2015) 10(5):33-40.
[2] Y. Tang, M.W. Lutz, Y.Xing, "A systems-based model of Alzheimer's disease",Alzheimers Dement.(2019)15(1):168-171.
[3] F. Kametani, M. Hasegawa,"Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's disease",Front Neurosci.(2018)12: 12-25.
[4] N.R. Naidu, S. Bhat, U. Dsouza,"Effect of long term administration of aluminum chloride on oxidative stress and acetylcholinesterase activity in rat brains", IJPBS(2013) 3(1):616-622.
[5] S.M.R. Wahba, A.S. Darwish, S.M. Kamal, "Ceria-containing uncoated and coated hydroxyapatite-based galantaminenanocomposites for formidable treatment of Alzheimer’s disease in ovariectomized albino-rat model", Mater Sci Eng C Mater Biol Appl.(2016) 65:151-163.
[6] S.M. Kamal, 2015 M.Sc. Thesis "Galantamine bioactivity improvement in rat brain using various novel nano-drug delivery systems as therapy for Alzheimer's disease", (Women's college for Arts, Sc. and Edu., Ain Shams University).
[7] G. Li, R. Bi, D. Zhang, M. Xu, R. Luo, D. Wang, Y. Fang, T. Li, C. Zhang, Y.Yao, "Female-specific effect of the BDNF gene on Alzheimer's disease", Neuro Biol Aging. (2017) 53(192): 11-19.
[8] M.L. Giuffrida, A. Copani, E. Rizzarelli, "A promising connection between BDNF and Alzheimer’s disease", Aging (Albany NY), (2018) 10(8): 1791–1792.
[11] A. Luarte, L.F. Bátiz, U. Wyneken,C. Lafourcade, "Potential therapies by stem cell-derived exosomes in CNS diseases: focusing on the neurogenic niche", Stem Cells Int., (2016) ID: 5736059.
[12] Z. Cai, M. Xiao,S.H. Quazi,Z. Ke, "Exosomes: a novel therapeutic target for Alzheimer’s disease?", Neural Regen. Res. (2018) 13(5):930-935.
[13] L.C. Liew, T. Katsuda, L. Gailhouste, H. Nakagama, T. Ochiya, "Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer’s disease", Int. Immunol. (2017) 29(1):11-19.
[18] E. GATTI, N.D. VIRGILIO, M. S. MAGLI, “PREDIERI, INTEGRATING SENSORY ANALYSIS AND HEDONIC EVALUATION FOR APPLE QUALITY ASSESSMENT” J. Food Qual.(2011) 34:126–132.
[19] A. Othman, R. Mubarak, M. Sameer, D. Sabry, “Fibroblast growth factor-6 enhances CDK2 and MAKT expression in microvesicles derived from human stem cells extracted from exfoliated deciduous teeth” F1000. (2019) 7:610-622.
[21] B.A. Berihu, M. Afwerk, Y.G. Debeb, A. Gebreslassie, "Review on Histological and Functional Effect of Aluminium Chloride on Cerebral Cortex of the Brain", IJPSR (2015) 6(8): 1105-1116.
[25] L. Jiang, H. Dong, H. Cao, X. Ji, S. Luan, J. Liu, "Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer’s Disease", Med Sci Monit.(2019) 25: 3329–3335.