The aim of the present study is to investigate the ameliorative effect of aqueous guava leaf extract (AGLE) with different doses (200, 350, 500 & 650 mg/kg b.wt.) taken p.o in rats fed high fat high cholesterol (HFC) diet for 8 weeks. The four doses of AGLE cause a significant decrease in food intake, final body weight, gain in body weight, serum TAG, VLDL-C, risk ratio as well as liver TAG and malondialdehyde level. Also doses of AGLE (350,500 and 650 mg/kg b.wt.) cause a significant decrease in relative liver weight, serum AST and LDL-C but a significant increase in HDL-C and leptin hormone. While doses (500 & 650 mg/kg b.wt.) cause a significant decrease in serum TC. The highest dose causes a significant decrease in serum ALT and adiponectin hormone. Total liver cholesterol was decreased significantly in groups given (200 & 350 mg/kg b.wt.) but no significant decrease in doses (500 & 650 mg/kg b.wt.). As well as ghrelin hormone does not show significant decrease in the four treated groups fed HFC diet and given AGLE compared to rats fed HFC diet only.
Abd El-Wahab, H., Galal, S., Abd El-Razik, F., & Sayed, D. (2016). Anti-hyperlipidemic and Anti-hypercholesterolemic effect of aqueous extract of guava (Pisidum guajava Linn.) leaves on rats. Journal of Scientific Research in Science, 33(part1), 565-584. doi: 10.21608/jsrs.2016.15327
MLA
Hanan M. F. Abd El-Wahab; Sahar M. Galal; Fatma H. Abd El-Razik; Dina H. Sayed. "Anti-hyperlipidemic and Anti-hypercholesterolemic effect of aqueous extract of guava (Pisidum guajava Linn.) leaves on rats". Journal of Scientific Research in Science, 33, part1, 2016, 565-584. doi: 10.21608/jsrs.2016.15327
HARVARD
Abd El-Wahab, H., Galal, S., Abd El-Razik, F., Sayed, D. (2016). 'Anti-hyperlipidemic and Anti-hypercholesterolemic effect of aqueous extract of guava (Pisidum guajava Linn.) leaves on rats', Journal of Scientific Research in Science, 33(part1), pp. 565-584. doi: 10.21608/jsrs.2016.15327
VANCOUVER
Abd El-Wahab, H., Galal, S., Abd El-Razik, F., Sayed, D. Anti-hyperlipidemic and Anti-hypercholesterolemic effect of aqueous extract of guava (Pisidum guajava Linn.) leaves on rats. Journal of Scientific Research in Science, 2016; 33(part1): 565-584. doi: 10.21608/jsrs.2016.15327