Synthesis and Characterization of Tb(III)-acetylacetone complex and its analytical application for hydrochlorothiazide determination in pharmaceutical preparation and biological fluids

Document Type : Original Article

Authors

1 Department of Chemistry, College of Women for Art, Science and Education, Ain Shams University, Cairo, Egypt

2 Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

3 Inorganic Chemistry Department, National Research Centre, 33- El-Behouth St. (former EL Tahrir St.), Dokki, Giza, Egypt, P.O.12622

4 Department of Chemistry, Faculty of Science, Helwan University, Helwan, Egypt

Abstract

Tb(III)-Acetylacetone complex  was prepared and characterized by elemental analysis, UV/Vis, FTIR, 1H-NMR spectroscopy, mass spectroscopy, conductance and magnetism. The results indicated that the complex composition is [Tb(ACAC)2(NO3)(EtOH)2(H2O)2]. The prepared complex was used as optical sensor for hydrochlorothiazide determination in pharmaceutical tablets and biological fluids (serum and urine). The hydrochlorothiazide can remarkably enhance the luminescence intensity of the complex in DMSO at λex/em = 285/545 nm and pH 6.3. The dynamic ranges found for the determination of hydrochlorothiazide concentration are 3.6 x 10-9 to 4.0 x 10-6 mol L-1, and the limit of detection (LOD) and quantitation limit of detection (LOQ) are 1.3 ×10−9 and 4.2 x 10-9 mol L-1, respectively.
 

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