In Vitro Effiacy Of Different Antibiotic Combinations On Aminoglycoside-Resistant Acinetobacter Baumannii

Ibrahim, Sarah Ibrahim Saad; Abdelhamid, Ferialla; Salah, Neveen Mohamed; Elsayed, Mohamed

doi:10.21608/jsrs.2019.30997

In Vitro Effiacy Of Different Antibiotic Combinations On Aminoglycoside-Resistant Acinetobacter Baumannii

Document Type : Original Article

Authors

¹ Assistant Prof. of Microbiology Botany and Microbiology deparment ,faculty for wamen for arts.Scinces and Education –Ain Shams Univerisity.

² Assistant Prof. of Microbiology,Microbiology deparment ,National Organization for Drug Control and Research (NODCAR).

³ Assistant Prof. of Microbiology,Microbiology deparment ,National Organization for Biological Control and Research (NODCAR).

10.21608/jsrs.2019.30997

Abstract

The potential synergy of combination of β-lactams(ceftriaxone, cefixime, carpabenem, and impenim)and aminoglycosides were tested against multidrug resistant Acinetobacter baumannii. Two-hundred bacterial pathogens were collected from Egyptian hospitals from various infection sites.One hundred and twentytwo isolates (60%) were resistant for aminoglycosides.Out of two-hundred strains,130 Acinetobacter baumannii strains (65%), were impenim resistant and nearly 180 Acinetobacter baumannii strains (90%),were resistant to cephalosporin. The MIC was determined for Acinetobacter baumanni istrains(32 to >512 mg/ml). In the checkerboard method, 38 combination from 45 combinations showed synergism for more than60% of the tested strains but only two demonstrated antagonism against 5 of tested strains. i.e. the ratio of synergy were detected for gentamycin with impenim, ceftriaxone and cefixime was 100%. Also synergism observed in case of combination between amakacin and tobramycin with ceftriaxone and cefixine with 100%,but in case of combination of tobramycin with imipenem showed ratio of synergy is 50% Whereas, combination between amakacin/impenim showed antagonism .

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